Hi Shannon,
Sorry to hear this about the tumors returning. I don’t think that technically Acyclovir for cats would help with this but I’m saying that because I don’t think it’s been researched. I suppose there’s no harm so you could go ahead but I don’t have the medical evidence to think that it would be beneficial. I found some posts in the research that suggest it may help with the discomfort that cancer brings but this is based on a single case only, it really means we have no evidence. The fact that it is an anti-viral drug, it should really not have any effect on a cancer.
My advice is to find a veterinary oncologist and go for at least an initial appointment. I would do this as soon as you can. They’ll give you a wealth of information even in the first appointment that would really educate you on your options. I STRONGLY recommend this.
Best of luck.
Dr. Clayton Greenway